🚀 Exciting news! Our latest research on the catalytic mechanism of GTP hydrolysis by RhoA has been accepted in ACS Catalysis! 🧪🔬 We reveal how glutamine tautomerism plays a crucial role in enzymatic activity.

This work provides a detailed computational investigation into the catalytic role of glutamine tautomerism in RhoA-mediated GTP hydrolysis, shedding light on fundamental enzymatic processes with broad implications for molecular biology and drug design. By combining quantum mechanics/molecular mechanics (QM/MM) simulations and advanced computational techniques, our findings offer new perspectives on how subtle electronic effects influence enzyme function.